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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“In vitro addition of lidocaine, disopyramide, bupivacaine, or quinidine in concentrations between 5 and 100 micrograms/mL, before dialysis, decreases the binding of diltiazem ; the displacing effect is most pronounced with bupivacaine.”
Binding of diltiazem to albumin, alpha 1-acid glycoprotein and to serum in man.“Clinically important interactions with other drugs may result from inhibition of the metabolism of certain drugs (carbamazepine, cyclosporine, quinidine ) by verapamil and/or diltiazem , inhibition of renal excretion (digoxin) by verapamil and diltiazem, and synergistic effects of beta blockers and verapamil.”
“The secretion of quinidine , well-known as an inhibitor of P-glycoprotein, was inhibited significantly and its absorption was enhanced significantly by several substrates of P-glycoprotein including verapamil, diltiazem , and digitoxin in jejunum.”
Role of P-glycoprotein as a secretory mechanism in quinidine absorption from rat small intestine.“Sparteine and quinidine , Ca(2+)-activated K+ channel blockade by diltiazem or nifedipine.”
“In contrast to verapamil, diltiazen lacks the ability to increase RET and AFT in the presence of quinidine ; diltiazen therefore cannot be expected to increase the antifibrillatory efficacy of quinidine in patients with atrial fibrillation.”
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