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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Diltiazem and Quinidine



Research Papers that Mention the Interaction

In vitro addition of lidocaine, disopyramide, bupivacaine, or quinidine in concentrations between 5 and 100 micrograms/mL, before dialysis, decreases the binding of diltiazem ; the displacing effect is most pronounced with bupivacaine.
Journal of clinical pharmacology  •  1990  |  View Paper
Clinically important interactions with other drugs may result from inhibition of the metabolism of certain drugs (carbamazepine, cyclosporine, quinidine ) by verapamil and/or diltiazem , inhibition of renal excretion (digoxin) by verapamil and diltiazem, and synergistic effects of beta blockers and verapamil.
Schweizerische medizinische Wochenschrift  •  1987  |  View Paper
The secretion of quinidine , well-known as an inhibitor of P-glycoprotein, was inhibited significantly and its absorption was enhanced significantly by several substrates of P-glycoprotein including verapamil, diltiazem , and digitoxin in jejunum.
Journal of pharmaceutical sciences  •  1998  |  View Paper
Sparteine and quinidine , Ca(2+)-activated K+ channel blockade by diltiazem or nifedipine.
Acta physiologica Scandinavica  •  1993  |  View Paper
In contrast to verapamil, diltiazen lacks the ability to increase RET and AFT in the presence of quinidine ; diltiazen therefore cannot be expected to increase the antifibrillatory efficacy of quinidine in patients with atrial fibrillation.
Zeitschrift fur Kardiologie  •  1982  |  View Paper