Possible Interaction: Diltiazem and Potassium

“ Diltiazem treatment increased net sodium efflux and potassium influx.(ABSTRACT TRUNCATED AT 250 WORDS)”

“ Diltiazem added to the medium before administration of the agonist, caused a concentration-dependent antagonism of potassium chloride-induced contractions in strips of rat detrusor and human detrusor.”

“The calcium channel antagonists, nifedipine, verapamil and diltiazem (0.01-10 microM), inhibited responses to high potassium , and the initial phase of shortening and lengthening responses to noradrenaline.”

“In ESRD, diltiazem significantly reduced the rate of increase in plasma potassium compared with placebo and resulted in a significantly lower net increase in potassium over the entire 28-hour period.”

“Although diltiazem moderately inhibited the rise in plasma IR-ET-1 and potassium concentration in these mice, it did not affect the accumulation of IR-ET-1 in the heart, lung or kidney.”

“CONCLUSIONS Although di tiazem su ppresses the early pot assium loss du ring ischaemia as previously described, the drug also decreases the [K+]e fall by some as yet unknown mechanism, so that the [K+]e level becomes higher than control during the falling phase.”

“6 These data indicate an involvement of potassium currents in the epileptiform activity elicited by high doses of diltiazem and verapamil.”

“The effect of the high potassium medium on catecholamine fluorescence was reduced by Ca++ influx inhibitors, diltiazem or Mg++.”

“Nicardipine and diltiazem in concentrations of 100 μmol l−1 reduced the potassium‐induced contraction to 33.0 ± 9.0% and 53.8 ± 6.7% of control respectively (n = 6, P < 0.05).”

“ Diltiazem (DZ) (10(-9)-10(-6) M) decreased the force and frequency of ureteral rhythmic contractions evoked by potassium or phenylephrine in a concentration-dependent manner, and relaxed potassium-contracted coronary artery strips.”