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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Diltiazem
supplement:
Epigallocatechin Gallate
Research Papers that Mention the Interaction
“The area under the plasma concentration-time curve (AUC) and the peak concentration (Cmax) of diltiazem were significantly (P < 0.05, 4 mg x kg(-1) and P < 0.01, 12 mg x kg(-1)) increased in the presence of EGCG.”
“The presence of EGCG significantly enhanced the oral bioavailability of diltiazem due to inhibiting cytochrome P450 (CYP) 3A4-mediated metabolism and P-glycoprotein (P-gp) mediated efflux of diltiazem in the intestine.”
Effects of epigallocatechin gallate on the bioavailability and pharmacokinetics of diltiazem in rats.
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