Possible Interaction: Diltiazem and Calcium Supplement

“ Diltiazem lowered serum PTH levels from 1.07 +/- 0.07 to 0.87 +/- 0.07 pg/L (P = 0.001), and increased urinary calcium and decreased urinary phosphate excretion (P less than 0.001 and P less than 0.01, respectively).”

“Thus the tension-suppressant effect of diltiazem in human myocardium appears to be mediated by a combination of voltage-dependent block of the Ca2+ channel and inhibition of Ca2+ release from internal stores, and not from alterations in either Na+-Ca2+ coupled transport or Ca2+ sensitivity of the myofilaments.”

“In rats the Ca antagonists verapamil and diltiazem not only prevented arterial calcinosis due to overdoses of vitamin D and dihydrotachysterol, but also counteracted age-dependent Ca accumulation.”

“ Diltiazem , nifedipine, and verapamil inhibit calcium entry into cells via different mechanisms with different pharmacologies.”

“The three major calcium channel blocking agents, diltiazem , nifedipine and verapamil, inhibit calcium entry into excitable cells.”

“In contrast, L-type Ca2+ channel blockade with diltiazem partially prevented (≈50%) the inotropic response to IGF-1.”

“However, the patient received an inadvertent bolus of diltiazem , causing a severe bradycardia that required multiple doses of calcium and a temporary pacemaker.”

“As a probable consequence, blood ionized calcium concentration was lower on diltiazem (1.14 mM +/- 0.02, mean +/- SEM) than on felodipine (1.2 +/- 0.03, P < 0.05) or in control condition (1.17 +/- 0.01, NS).”

“This study showed that the use of calcium-free cardioplegic solution caused intracellular calcium accumulation in a hypothermic global ischemic and reperfused conditions during coronary surgery, whereas, diltiazem could suppress the calcium accumulation.”

“These data suggested that diltiazem could suppress intracellular calcium accumulation and keep homeostasis of sodium-potassium pump mechanism in membrane during reperfusion.”