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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Diindolylmethane and Docetaxel

Research Papers that Mention the Interaction

We conclude that inactivation of FoxM1 and its target genes by DIM could enhance the therapeutic efficacy of Taxotere in breast cancer, which could be a useful strategy for the prevention and/or treatment of breast cancer.
International journal of cancer  •  2011  |  View Paper
Conclusions: Our findings indicated that DIM enhances the sensitivity of breast cancer cells to DOC treatment by increasing ROS, which led to decreased cell survival and apoptosis.
Results: Combining 25 µM of DIM with 1 nM DOC decreased cell survival by 42% in MDA-MB231 cells and 59% in Sk-BR-3 cells compared to control, DIM, or DOC (p ≤ 0.05).
Pharmaceutical biology  •  2018  |  View Paper