Possible Interaction: Dihydroxyphenylalanine and S-Adenosylmethionine

“As little as 10 milligrams of L-dihydroxyphenylalanine per kilogram decreased content of S-adenosylmethionine in the adrenal medulla by 51 percent, whereas 100 milligrams per kilogram did not significantly depress concentration of S-adenosylmethionine in the liver in this time interval.”

“Forty-five minutes after intraperitoneal injection of a single dose (100 milligrams per kilogram) of L-dihydroxyphenylalanine , the concentration of S-adenosylmethionine in rat brain was lowered by 76 percent.”