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Discover Supplement-Drug Interactions

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Last Updated: 2 months ago

Possible Interaction: Dihydroxyphenylalanine and Melatonin

Research Papers that Mention the Interaction

It is evident that 5-HTP and L-DOPA given at the interval of 8h, as well as melatonin , are potent inhibitors of gonadal development, and the gonado stimulatory effect of the 12-h temporal relationship of the neurotransmitter precursors is masked by the inhibitory effect of melatonin.
Domestic animal endocrinology  •  2009  |  View Paper
Co-infusion of N-acetylcysteine (100 microm) or melatonin (50 microm) increased L-DOPA (up to 151- and 246-fold, respectively) and decreased L-DOPA-SQ (by about 53% and 87%, respectively) dialysate concentrations.
These findings demonstrate that endogenous melatonin protects exogenous L-DOPA from autoxidation in the extracellular compartment of the striatum of freely moving rats; moreover, systemic co-administration of melatonin with L-DOPA markedly increases striatal L-DOPA bioavailability in control as well as in melatonin-depleted rats.
Journal of pineal research  •  2006  |  View Paper