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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Dihydroxyphenylalanine and Manganese

Research Papers that Mention the Interaction

In rats given L‐DOPA either systemically or intrastriatally, intrastriatal infusion of manganese decreased L‐DOPA dialysate concentrations and greatly increased those of L‐DOPA semiquinone.
L‐DOPA auto‐oxidation is inhibited by NAC and enhanced by manganese.
We have previously shown that manganese enhances L‐dihydroxyphenylanine (L‐DOPA) toxicity to PC12 cells in vitro.
British journal of pharmacology  •  2000  |  View Paper
However, manganese ions initiate the oxidation of DOPA to yield dopachrome.
Guang pu xue yu guang pu fen xi = Guang pu  •  2005  |  View Paper