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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Iron, Dietary
Research Papers that Mention the Interaction
“Conversely, l‐DOPA has pH‐dependent Fe‐chelating properties, and may act to ‘redox silence’ Fe and partially allay DA autoxidation.”
“We found that l‐DOPA was neuroprotective and prevented age‐related Fe accumulation in the substantia nigra pars compacta (SNc), similar to the mild‐affinity Fe chelator clioquinol.”
l‐3,4‐dihydroxyphenylalanine (l‐DOPA) modulates brain iron, dopaminergic neurodegeneration and motor dysfunction in iron overload and mutant alpha‐synuclein mouse models of Parkinson's disease“The released iron induced lipid peroxidation at relatively low concentrations of DA or DOPA , while at high concentrations, peroxidation was inhibited.”
Dopamine and DOPA cause release of iron from ferritin and lipid peroxidation of liposomes.“These results indicate that Dopa initiates lipid peroxidation of cell membrane in the presence of a small amount of iron in the culture with little or no participation of reactive oxygen species, leading to the destruction of the neurons.”
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