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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Gamma-Aminobutyric Acid
Research Papers that Mention the Interaction
“A single injection of L-DOPA enhanced GABA release in the medial globus pallidus on the lesioned side in L-DOPA-induced dyskinesia-model rats compared to Parkinson's disease-model rats.”
GABA storage and release in the medial globus pallidus in L-DOPA-induced dyskinesia priming“ GABA seems to inhibit tonically via GABA(A) receptors depressor responses to DOPA and to elicit pressor responses partially by inhibition of tonic function of endogenous DOPA to activate depressor sites in the NTS.”
“Prior DOPA ME (1 microg) inhibited by one-half pressor responses to 300 ng GABA.”
“Responses to DOPA (30 ng) were inhibited by pretreatment with GABA and nipecotic acid, but potentiated by bicuculline, when vascular responses to pretreated drugs returned to basal levels.”
“Endogenous GABA seems to regulate tonically basal DOPA release via activation of inhibitory GABA(A) receptors in the rat NTS.”
“Moreover, the threonine phosphorylation of DARPP‐32 produced by maximally effective doses of either forskolin (in striatum) or l‐3,4‐dihydroxyphenylalanine (in substantia nigra) was increased further by GABA.”
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