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Last Updated: 2 years ago

Possible Interaction: Dihydroxyphenylalanine and Cupric Cation

Research Papers that Mention the Interaction

DOPA at relatively low concentrations showed a concentration-dependent inactivation of PON1 in a concert with Cu2+ , but not Fe2+.
Separately, it was found that DOPA at low concentrations (1-6 μM) acted as a pro-oxidant by enhancing Cu2+ -induced oxidation of HDL, while it exhibited an antioxidant action at ≥10 μM. In addition, Cu2+-oxidized HDL lost the antioxidant action against LDL oxidation.
Free radical research  •  2004  |  View Paper
It was observed that 15.75 micrograms of cupric ions were reduced by 12.12 micrograms of DOPA.
Acta morphologica Hungarica  •  1988  |  View Paper
Ferric or cupric ion significantly promoted a peroxidative cleavage in liposomes (model membranes) after coordinating with dopa or dopamine.
European neurology  •  1993  |  View Paper
CUPRIC ions are known to accelerate the autoxidation of dihydroxyphenylalanine.
Nature  •  1957  |  View Paper
Abstract Though cupric ions were not essential for dopa autoxidation, the oxidation rate of dopa was increased by cupric-plasma protein complexes and, to a lesser extent, by cupric ions.
Archives of biochemistry and biophysics  •  1957  |  View Paper
IT is said that cupric ions accelerate the autoxidation of 3,4-dihydroxyphenylalanine (dopa)1 and, on the other hand, that they combine with pterins, riboflavin, amino-acids and other organic substances to form chelate complexes2.
Nature  •  1953  |  View Paper