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“ DOPA at relatively low concentrations showed a concentration-dependent inactivation of PON1 in a concert with Cu2+ , but not Fe2+.”
“Separately, it was found that DOPA at low concentrations (1-6 μM) acted as a pro-oxidant by enhancing Cu2+ -induced oxidation of HDL, while it exhibited an antioxidant action at ≥10 μM. In addition, Cu2+-oxidized HDL lost the antioxidant action against LDL oxidation.”
“Abstract Though cupric ions were not essential for dopa autoxidation, the oxidation rate of dopa was increased by cupric-plasma protein complexes and, to a lesser extent, by cupric ions.”
Archives of biochemistry and biophysics • 1957 | View Paper
“IT is said that cupric ions accelerate the autoxidation of 3,4-dihydroxyphenylalanine (dopa)1 and, on the other hand, that they combine with pterins, riboflavin, amino-acids and other organic substances to form chelate complexes2.”