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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Dihydrotestosterone
supplement:
Tretinoin
Research Papers that Mention the Interaction
“In additional studies, retinoic acid induced a dose-dependent … at concentrations of 0.1 to 1 microM. Dihydrotestosterone (10 nM.) also enhanced the secretion of PSA by … in a dose-dependent fashion by the addition of retinoic acid at 0.1-10 microM. Competitive … not bind to androgen receptors.”
“In the presence of 0.1 nM. dihydrotestosterone DHT ), LNCaP cell proliferation was inhibited by 10 microM. retinoic acid but not by lower concentrations of retinoic acid.”
Effect of retinoic acid on the proliferation and secretory activity of androgen-responsive prostatic carcinoma cells.“The conversion of testosterone to DHT by 5α‐reductase was reduced in the presence of retinoic acid.”
“These RAs also decreased [3H]thymidine labeling indexes of both epithelium and mesenchyme of SVs cultured in medium with DHT plus insulin or DHT alone and inhibited the increase in their protein contents.”
Inhibitory effects of retinoic acids on androgen-dependent development of neonatal mouse seminal vesicles in vitro.
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