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Discover Supplement-Drug Interactions

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Last Updated: 2 months ago

Possible Interaction: Dihydrotestosterone and Threonine

Research Papers that Mention the Interaction

Replacement of M107 with threonine resulted in a tenfold decrease in 5 alpha-dihydrotestosterone binding affinity , whereas replacement with leucine left the K(d) unchanged.
The Journal of Steroid Biochemistry and Molecular Biology  •  2000  |  View Paper
Moreover, a co-culture system featuring outer root sheath (ORS) keratinocytes and DPCs showed that DHT inhibited the growth of ORS cells, which was then significantly reversed by L-threonate.
BMB reports  •  2010  |  View Paper
Obtained results indicate that DHT treatment significantly decreased cardiac eNOS protein level and activating phosphorylation at serine 1,177, while inhibitory phosphorylation at threonine 495 was increased.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association  •  2015  |  View Paper