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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Dihydrotestosterone and Genistein

Research Papers that Mention the Interaction

Hydroxyflutamide, RU58841, and Casodex, but not genistein , displayed competitively suppressive effects on DHT activation of wt AR.
Endocrine  •  1998  |  View Paper
In cell signaling, both HPCD and genistein decreased the protein expressions of pAkt as well as the androgen receptors stimulated by EGF and DHT , respectively, in concentration-dependent manners.
Biochemical and biophysical research communications  •  2010  |  View Paper
Genistein at 50 micro mol/L completely inhibited expression … PART-1 transcript in LNCaP cells induced by DHT at 0.1 and 1.0 nmol/L. Daidzein was less potent than genistein, whereas glycitein … same levels as genistein or daidzein did not inhibit DHT-induced PART-1 transcript expression.
The Journal of nutrition  •  2003  |  View Paper
Genistein but not 17α-estradiol also inhibited prostate 5α-reductase-2 mRNA and intraprostatic dihydrotestosterone induced by the high fat diet at 2 weeks.
The Journal of urology  •  2011  |  View Paper