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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Dihydrotestosterone
supplement:
Genistein
Research Papers that Mention the Interaction
“Hydroxyflutamide, RU58841, and Casodex, but not genistein , displayed competitively suppressive effects on DHT activation of wt AR.”
Evaluation of RU58841 as an anti-androgen in prostate PC3 cells and a topical anti-alopecia agent in the bald scalp of stumptailed macaques“In cell signaling, both HPCD and genistein decreased the protein expressions of pAkt as well as the androgen receptors stimulated by EGF and DHT , respectively, in concentration-dependent manners.”
“ Genistein at 50 micro mol/L completely inhibited expression … PART-1 transcript in LNCaP cells induced by DHT at 0.1 and 1.0 nmol/L. Daidzein was less potent than genistein, whereas glycitein … same levels as genistein or daidzein did not inhibit DHT-induced PART-1 transcript expression.”
“ Genistein but not 17α-estradiol also inhibited prostate 5α-reductase-2 mRNA and intraprostatic dihydrotestosterone induced by the high fat diet at 2 weeks.”
17α-Estradiol and genistein inhibit high fat diet induced prostate gene expression and prostate growth in the rat.
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