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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Dihydrotestosterone
supplement:
Diindolylmethane
Research Papers that Mention the Interaction
“Both I3C and DIM inhibited promotional effects of dihydrotestosterone on CCL2 and migration.”
Indole-3-Carbinol and 3′,3′-Diindolylmethane Modulate Androgen's Effect on C-C Chemokine Ligand 2 and Monocyte Attraction to Prostate Cancer Cells“ DIM suppresses cell proliferation of LNCaP cells and inhibits dihydrotestosterone (DHT) stimulation of DNA synthesis.”
“Moreover, DIM inhibited endogenous PSA transcription and reduced intracellular and secreted PSA protein levels induced by DHT in LNCaP cells.”
“Results of receptor binding assays indicated further that DIM is a strong competitive inhibitor of DHT binding to the AR.”
Plant-derived 3,3′-Diindolylmethane Is a Strong Androgen Antagonist in Human Prostate Cancer Cells*
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