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Discover Supplement-Drug Interactions

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Last Updated: 3 months ago

Possible Interaction: Dihydroergotamine and Ergotamine

Research Papers that Mention the Interaction

Significant pharmacologic and safety differences exist between ET and DHE.
Headache  •  1997  |  View Paper
In order to avoid drug-induced headache ergotamine and DHE should not be used daily.
Current medical research and opinion  •  2001  |  View Paper
The discrepancy in the peripheral effects of ergotamine and dihydroergotamine might also be of clinical Importance. (
Stroke  •  1987  |  View Paper
In experiments on bile fistula monkeys, it was shown that the hepatic distribution ratio is, in fact, constant, despite the fact that the enteral absorption of ergotamine is 3 times that of dihydroergotamine.
Journal of Pharmacokinetics and Biopharmaceutics  •  2005  |  View Paper
Dihydroergotamine did not contract the tissue, but insurmountably blocked contraction in response to ergotamine and 5-HT.
Pharmacology  •  1996  |  View Paper
Ergotamine and dihydroergotamine significantly decreased the fraction of carotid blood flow shunted through the arteriovenous anastomoses, a mode of action that reemphasizes the need for further clinical studies on the involvement of arteriovenous anastomoses in the pathophysiology of migraine headaches.
Neurology  •  1980  |  View Paper
For example, DHE is less potent than ERG by about ten-fold at the 5-hydroxytrptamine receptor 1B (5-HT1B).
J. Chem. Inf. Model.  •  2020  |  View Paper