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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Dihydroergotamine
supplement:
Ergotamine
Research Papers that Mention the Interaction
“Significant pharmacologic and safety differences exist between ET and DHE.”
Ergotamine tartrate and dihydroergotamine mesylate: safety profiles.“In order to avoid drug-induced headache ergotamine and DHE should not be used daily.”
“The discrepancy in the peripheral effects of ergotamine and dihydroergotamine might also be of clinical Importance. (”
“In experiments on bile fistula monkeys, it was shown that the hepatic distribution ratio is, in fact, constant, despite the fact that the enteral absorption of ergotamine is 3 times that of dihydroergotamine.”
Ergot alkaloids: Hepatic distribution and estimation of absorption by measurement of total radioactivity in bile and urine“ Dihydroergotamine did not contract the tissue, but insurmountably blocked contraction in response to ergotamine and 5-HT.”
“ Ergotamine and dihydroergotamine significantly decreased the fraction of carotid blood flow shunted through the arteriovenous anastomoses, a mode of action that reemphasizes the need for further clinical studies on the involvement of arteriovenous anastomoses in the pathophysiology of migraine headaches.”
“For example, DHE is less potent than ERG by about ten-fold at the 5-hydroxytrptamine receptor 1B (5-HT1B).”
Binding Interactions of Ergotamine and Dihydroergotamine to 5-Hydroxytryptamine Receptor 1B (5-HT1b) Using Molecular Dynamics Simulations and Dynamic Network Analysis
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