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Last Updated: 2 years ago

Possible Interaction: Dihydroergotamine and Epinephrine

Research Papers that Mention the Interaction

Though platelet function ex vivo was unchanged, inhibition of adrenaline induced platelet aggregation was noted in vitro when the plasma concentrations of added DHE were higher than those obtained with clinically relevant doses.
Thrombosis research  •  1983  |  View Paper
Dihydroergotamine (DHE) inhibited epinephrine induced platelet aggregation (ID50 = 2.5 X 10(-7) mol/l), and increased cAMP levels in platelets by an alpha-adrenergic receptor blocking effect, since phentolamine but not propranolol, behaved similarly.
Arzneimittel-Forschung  •  1987  |  View Paper
3) The inhibition of VIP action by epinephrine is reversed by the alpha antagonists dihydroergotamine , phentolamine and the alpha 2 antagonist yohimbine, while unaffected by the beta antagonist propranolol and the alpha 1 antagonist prazosin, (4) Epinephrine inhibits VIP-stimulated adenylate cyclase activity in preparations of colonic plasma membranes.
Peptides  •  1984  |  View Paper
5 The concentration of metabolite in the platelets increased with the concentration of added adrenaline only up to about 2 × 10−4m. 6 The immediate uptake of adrenaline was partially inhibited by phentolamine and dihydroergotamine.
British journal of pharmacology  •  1970  |  View Paper
Sm,-Wiqvist (1959) presented evidence that the inhibitory action of relaxin on the spontaneous contractions of the isolated uterus of the rat was not blocked either by phentolamine or by dihydroergotamine in concentrations which blocked the inhibition of the these contractions by adrenaline.
The Journal of pharmacy and pharmacology  •  1965  |  View Paper
Dibenamine, dihydroergotamine , regitin and priscol were found to antagonize specifically the inhibitory action of adrenaline and noradrenaline on the electrically stimulated isolated ileum of the guinea-pig.
Experientia  •  1958  |  View Paper
Doses of dihydroergotamine of 1 to 1.5 mg were found to have only a slight inhibitory effect on the action of adrenaline , administered intravenously.
Acta physiologica Scandinavica  •  1952  |  View Paper
Also, pretreatment with dihydroergotamine antagonized the hyperglycaemic effect of adrenaline and prevented that of dopamine and noradrenaline, while the effect of catecholamines on plasma glycerol concentration was not affected.
Naunyn-Schmiedeberg's Archives of Pharmacology  •  2004  |  View Paper
The adrenergic antagonist dihydroergotamine blocked the effects of epinephrine.
Molecular pharmacology  •  1990  |  View Paper
In contrast, dihydroergotamine abolished and phentolamine diminished the induction of alpha-aminoisobutyric acid transport by epinephrine but did not decrease the stimulation of cAMP levels by epinephrine.
Proceedings of the National Academy of Sciences of the United States of America  •  1977  |  View Paper
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