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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Dihydroartemisinin
supplement:
Iron, Dietary
Research Papers that Mention the Interaction
“As a result, DHA effectively decreased the TfR content and down-regulated TfR protein expression in normal iron HL60 and K562 cells in a dose- and time-dependent manner and inhibited the cell proliferation.”
“Moreover, DHA decreased the iron content of iron overload K562 cells and inhibited the proliferation of iron overload K562 cells more potently.”
[Dihydroartemisinin down-regulates the expression of transferrin receptor in myeloid leukemia cells].“In the presence of iron, dihydroartemisinin forms free radicals and causes cell death.”
Oral administration of dihydroartemisinin and ferrous sulfate retarded implanted fibrosarcoma growth in the rat.“Therefore, iron may be a potential adjuvant for DHA in osteosarcoma treatment.”
Iron Promotes Dihydroartemisinin Cytotoxicity via ROS Production and Blockade of Autophagic Flux via Lysosomal Damage in Osteosarcoma“Although heme usually reacts faster with artemisinins than iron does, we have found that rearrangement of dihydroartemisinin (DHA) into monoketo-aldehyde-peroxyhemiacetal (MKA) under physiological conditions can significantly enhance its reaction towards iron.”
“In addition, the Fe ions releasedfrom the MOFs in the tumor environment not only enhanced the curative effect of DHA but also catalyzed H2O2 to release O2, which further improved the photodynamic therapeutic effect of the nanocomposites.”
“In addition, we demonstrated that inhibition of the proliferation of leukemia K562 cells by DHA is also dependent upon iron.”
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