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Last Updated: 2 years ago

Possible Interaction: Dihydroartemisinin and Iron, Dietary

Research Papers that Mention the Interaction

As a result, DHA effectively decreased the TfR content and down-regulated TfR protein expression in normal iron HL60 and K562 cells in a dose- and time-dependent manner and inhibited the cell proliferation.
Moreover, DHA decreased the iron content of iron overload K562 cells and inhibited the proliferation of iron overload K562 cells more potently.
Yao xue xue bao = Acta pharmaceutica Sinica  •  2008  |  View Paper
In the presence of iron, dihydroartemisinin forms free radicals and causes cell death.
Cancer letters  •  1995  |  View Paper
Therefore, iron may be a potential adjuvant for DHA in osteosarcoma treatment.
Frontiers in Pharmacology  •  2020  |  View Paper
Although heme usually reacts faster with artemisinins than iron does, we have found that rearrangement of dihydroartemisinin (DHA) into monoketo-aldehyde-peroxyhemiacetal (MKA) under physiological conditions can significantly enhance its reaction towards iron.
Free radical biology & medicine  •  2020  |  View Paper
In addition, the Fe ions releasedfrom the MOFs in the tumor environment not only enhanced the curative effect of DHA but also catalyzed H2O2 to release O2, which further improved the photodynamic therapeutic effect of the nanocomposites.
ACS biomaterials science & engineering  •  2019  |  View Paper
In addition, we demonstrated that inhibition of the proliferation of leukemia K562 cells by DHA is also dependent upon iron.
FEBS open bio  •  2012  |  View Paper