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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Digoxin
supplement:
Tryptophan
Research Papers that Mention the Interaction
“ Digoxin can also … upregulate tryptophan transport over tyrosine resulting in increased levels of depolarizing tryptophan catabolites--serotonin, quinolinic acid (NMDA agonist), strychnine (blocks glycinergic inhibitory transmission), and nicotine (promotes dopamine release) and decreased levels of hyperpolarizing tyrosine catabolites--dopamine, noradrenaline, and morphine--contributing to membrane Na+-K+ ATPase inhibition.”
A HYPOTHALAMIC DIGOXIN-MEDIATED MODEL FOR AUTISM“ Digoxin can also … upregulate tryptophan transport over tyrosine resulting in increased levels of depolarising tryptophan catabolites – serotonin, quinolinic acid, strychnine and nicotine and decreased levels of hyperpolarising tyrosine catabolites dopamine, noradrenaline and morphine contributing to membrane Na+–K+ ATPase inhibition in all the above disorders and the indexed family.”
“ Digoxin can regulate neurotransmitter transport in the brain with upregulation of tryptophan transport over tyrosine.”
“ Digoxin can also … upregulate tryptophan transport over tyrosine, resulting in increased levels of depolarizng tryptophan catabolites, serotonin, quinolinic acid, strychnine, and nicotine, and decreased levels of hyperpolarizing tyrosine catabolites, dopamine, noradrenaline, and morphine, contributing to membrane Na ´ +;-K ´ +; ATPase inhibition in all the above disorders and the indexed family.”
“ Digoxin can also preferentially upregulate tryptophan transport over tyrosine resulting in increased levels of depolarising tryptophan catabolites – serotonin and quinolinic acid (NMDA agonist), and decreased levels of hyperpolarising tyrosine catabolites – dopamine and noradrenaline contributing to membrane Na+-K+ ATPase inhibition.”
“ Digoxin also influences transport of tryptophan and tyrosine which are precursors of various neurotransmitters.”
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