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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“The hypothesis tested was that specific flavonoids such as epicatechin gallate, epigallocatechin gallate, genistein, genistin, naringenin, naringin, quercetin and xanthohumol will modulate cellular uptake and permeability (Pe) of multidrug-resistant substrates, cyclosporin A (CSA) and digoxin , across Caco-2 and MDCKII-MDR1 cell transport models.”
Plant polyphenols and multidrug resistance: Effects of dietary flavonoids on drug transporters in Caco-2 and MDCKII-MDR1 cell transport models“The coadministration of 40 mg/kg quercetin significantly elevated the Cmax of digoxin by 413% and increased the AUC0-t by 170%.”
“The coadministration of 50 mg/kg quercetin unexpectedly resulted in sudden death of two among three pigs within 30 min after digoxin administration.”
“The concomitant administration of digoxin and quercetin or quercetin-containing herbs and dietary supplement should be avoided.”
“The results indicated that a very serious pharmacokinetic interaction occurred between quercetin and digoxin.”
Lethal quercetin-digoxin interaction in pigs.“The apical to basolateral transport of digoxin was increased where as basolateral to apical transport of digoxin was decreased in concentration dependent manner in the presence of elacridar, quercetin and silymarin.”
Natural flavonoids silymarin and quercetin improve the brain distribution of co-administered P-gp substrate drugs
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