Possible Interaction: Digoxin and Magnesium

“Conclusions: Adding intravenous magnesium to digoxin reduces fast ventricular response in acute onset atrial fibrillation.”

“When compared to placebo, adding intravenous magnesium to digoxin increased the proportion of patients with a ventricular response <100 beats/min (58.8% vs 32.6%; OR 3.2, 95% CI 1.93 to 5.42; p<0.001).”

“ Magnesium improves the efficacy of digoxin in slowing the ventricular response in atrial fibrillation.”

“ Magnesium , acting as an indirect antagonist of digoxin at the sarcolemma Na(+)-K(+)-ATPase pump, reduces cardiac arrhythmias due to digoxin poisoning.”

“Recent controlled studies have shown that treatment with magnesium significantly reduces the frequency and complexity of ventricular arrhythmias in digoxin-treated patients with congestive heart failure without digoxin toxicity.”

“Typical therapy for heart failure digoxin , diuretic agents, and ACE inhibitors) are influenced by or associated with significant alteration in magnesium balance.”

“ Magnesium is known to suppress early after depolarizations, and in supraphysiological doses, may act as an indirect antagonist of digoxin at the sarcolemma Na(+)-K(+)-ATPase pump.”

“ Digoxin directly limits the renal tubular reabsorption of magnesium , therefore increasing magnesium excretion.”

“On the other hand, by temporarily impairing renal function and reducing the plasma concentrations of potassium and magnesium , it tends to reduce maintenance requirements of digoxin.”

“Excess magnesium enhanced the increase in e. p. p. amplitude produced by digoxin , especially when the calcium concentration was low.”

“The incorporation of magnesium oxide and magnesium hydroxide-aluminum hydroxide in the tablet formulations inhibited digoxin hydrolysis by 15.3 and 14.5%, respectively, after dissolution for 30 min without serious delay of drug release.”