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Discover Supplement-Drug Interactions

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Last Updated: 6 months ago

Possible Interaction: Digoxin and Glabridin

drug:

Digoxin

supplement:

Glabridin

Research Papers that Mention the Interaction

Glabridin inhibited PgP-mediated transport of digoxin with an IC50 value of 2.56 μM, but stimulated PgP/MDR1 ATPase activity with a Km of 25.1 μM. The plasma AUC0–24h of glabridin in mdr1a(–/–) mice was 3.8-fold higher than that in wild-type mice.
Drug Metabolism and Disposition  •  2007  |  View Paper