Possible Interaction: Digoxin and Ginseng

“Abbott Laboratories … two new digoxin assays : iDigoxin, a chemiluminescent microparticle immunoassay for application on the ARCHITECT i1000SR and i2000SR immunoassay analyzers, and cDigoxin, a particle‐… immunoassay for application on the ARCHITECT c4000, c8000, and c1600 clinical chemistry analyzers; and we studied potential interferences of ginsengs with these … in vitro.”

“Asian, Siberian, and American ginseng are known to interfere with serum digoxin measurements using fluorescence polarization technology, Digoxin II and Digoxin III assays (Abbott Laboratories, Green oaks, IL) as well as other digoxin assays.”

“It is known that ingestion of ginseng can cause falsepositive readings of digoxin in certain immunoassays; however, bradyarrhythmia caused by ginseng-associated digitalis glycoside–like effect has not been reported before.”

“Kyushin, licorice, plantain, uzara root, hawthorn, and ginseng may interfere with either digoxin pharmacodynamically or with digoxin monitoring.”