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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“The hypothesis tested was that specific flavonoids such as epicatechin gallate, epigallocatechin gallate, genistein , genistin, naringenin, naringin, quercetin and xanthohumol will modulate cellular uptake and permeability (Pe) of multidrug-resistant substrates, cyclosporin A (CSA) and digoxin , across Caco-2 and MDCKII-MDR1 cell transport models.”
Plant polyphenols and multidrug resistance: Effects of dietary flavonoids on drug transporters in Caco-2 and MDCKII-MDR1 cell transport models“We found that among flavonoids, genistein (200 μM), found in soy and other legumes, but not quercetin (10, 30, 100, 330 μM) or the 3-β-glycoside isoquercetrin (100 μM), significantly increased digoxin accumulation.”
A new method to measure intestinal activity of P-glycoprotein in avian and mammalian species
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