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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Digoxin
supplement:
Epinephrine
Research Papers that Mention the Interaction
“ ADR infusions caused significant and dose-dependent decreases in serum digoxin (p < 0.05 during ADR-L and p < 0.001 during ADR-H) and serum potassium (p < 0.05 and p < 0.001, respectively).”
“Thus, ADR caused dose-dependent shifts of digoxin and potassium, whereas mental stress failed to do so, possibly due to a modest ADR response and small increases in sympathetic nerve activity in skeletal muscle.”
Effects of Adrenaline and Mental Stress on Serum Digoxin Concentration“Only the concentration of adrenaline was higher (p < 0.05) in the group of patients with therapeutic concentrations of digoxin.”
“Infusion of epinephrine 0.1 μg/min for 45 min in 4 subjects after the 30-min infusion of digoxin resulted in similar increases in forearm blood flow and lactate production as with the epinephrine infusions alone; however, arterio-venous differences for free fatty acids were significantly reduced.”
“The cardiotoxic dose of digoxin was markedly reduced by epinephrine , not by doxaminol.”
“The combined infusion of epinephrine (0.3 micrograms/kg X min) plus digoxin (10 micrograms/kg X min) caused a maximal increase of dp/dtmax by 7.9 mHg/s.”
Increase in the cardiotonic action and in the therapeutic margin of digoxin by the adrenergic beta-stimulant doxaminol in cats.
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