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Last Updated: 2 years ago

Possible Interaction: Digoxin and Epinephrine

drug:

Digoxin

supplement:

Epinephrine

Research Papers that Mention the Interaction

ADR infusions caused significant and dose-dependent decreases in serum digoxin (p < 0.05 during ADR-L and p < 0.001 during ADR-H) and serum potassium (p < 0.05 and p < 0.001, respectively).
Thus, ADR caused dose-dependent shifts of digoxin and potassium, whereas mental stress failed to do so, possibly due to a modest ADR response and small increases in sympathetic nerve activity in skeletal muscle.
Journal of cardiovascular pharmacology  •  1991  |  View Paper
Only the concentration of adrenaline was higher (p < 0.05) in the group of patients with therapeutic concentrations of digoxin.
International journal of clinical pharmacology research  •  1998  |  View Paper
Infusion of epinephrine 0.1 μg/min for 45 min in 4 subjects after the 30-min infusion of digoxin resulted in similar increases in forearm blood flow and lactate production as with the epinephrine infusions alone; however, arterio-venous differences for free fatty acids were significantly reduced.
The Journal of clinical endocrinology and metabolism  •  1973  |  View Paper
The cardiotoxic dose of digoxin was markedly reduced by epinephrine , not by doxaminol.
The combined infusion of epinephrine (0.3 micrograms/kg X min) plus digoxin (10 micrograms/kg X min) caused a maximal increase of dp/dtmax by 7.9 mHg/s.
Arzneimittel-Forschung  •  1985  |  View Paper