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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Digoxin
supplement:
Epigallocatechin Gallate
Research Papers that Mention the Interaction
“The hypothesis tested was that specific flavonoids such as epicatechin gallate, epigallocatechin gallate , genistein, genistin, naringenin, naringin, quercetin and xanthohumol will modulate cellular uptake and permeability (Pe) of multidrug-resistant substrates, cyclosporin A (CSA) and digoxin , across Caco-2 and MDCKII-MDR1 cell transport models.”
Plant polyphenols and multidrug resistance: Effects of dietary flavonoids on drug transporters in Caco-2 and MDCKII-MDR1 cell transport models“Compared to … of digoxin … GTC significantly reduced the systemic exposure of digoxin: geometric mean ratios (GMR) and 90% confidence intervals (CI) of area under the concentration–time … the last measurable time (AUClast) and Cmax were 0.69 (0.62–0.75) and 0.72 (0.61–0.85), respectively.”
“Conclusion This study demonstrates that the coadministration of GTC reduces the systemic exposure of digoxin regardless of pretreatment of GTC.”
“The concomitant administration of digoxin and GTC following pretreatment of GTC (Day 29) similarly reduced the AUClast (GMR [90% CI]: 0.67 [0.61–0.74]) and Cmax (GMR [90% CI]: 0.74 [0.63–0.87]).”
“Basolateral to apical transport of digoxin was significantly decreased in the presence of green tea and EGCG.”
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