Possible Interaction: Digoxin and Calcium Supplement

“A correlation of borderline significance was found between Fex Ca and serum Digoxin (r = 0.349, p = 0.073).”

“■ This supplement should be taken at least 2 hours apart from prescription medications as both fiber and calcium can affect absorption of certain medications, particularly tetracycline and floroquinolone antibiotics, levothyroxine, and digoxin.”

“Care should be exercised to avoid the administration of calcium in the setting of concomitant digoxin toxicity.”

“It is concluded that in addition to RBC Na+ and K+ levels, intra-erythrocyte levels of calcium are sensitive indicators of digoxin effect; and that penicillamine reverses digoxin-induced RBC electrolyte alterations towards pre-digitalization values.”

“2) Preincubation of mast cells with 10−4 mol/l liposoluble glycosides (digitoxine, digoxine , digitoxigenine) decreases histamine release induced by compound 48/80 in the presence of calcium , whereas the water soluble glycoside, strophanthin G, has no effect on the secretion. (”

“ Digoxin increases intracellular calcium by inhibiting the sodium-potassium adenosine triphosphatase enzymes.”

“ Digoxin at concentrations ranging between 0.2-5.0 ng/ml in the incubation solution increased significantly (P less than 0.5) intracellular calcium in the diaphragm muscle strips in a dose-dependent pattern.”

“The dilator effect of the highest dose of calcium was reversed by digoxin , suggesting the involvement of Na+,K+-ATPase.”