supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
drug:
Digoxin
supplement:
Biochanin A
Research Papers that Mention the Interaction
“The 1.5-h accumulation of digoxin and vinblastine in Caco-2 cells was significantly increased by 50 μM biochanin A or silymarin, and this effect was flavonoid-concentration dependent.”
Effect of the Flavonoids Biochanin A and Silymarin on the P-Glycoprotein-Mediated Transport of Digoxin and Vinblastine in Human Intestinal Caco-2 Cells“ BA may suboptimally inhibit Pgp and CYP3A, resulting in a moderate increase in oral bioavailability of digoxin.”
“With BA coadministration, the oral bioavailability and peak plasma concentration were markedly increased by 3.77- and 2.04-fold for paclitaxel, 1.75- and 1.71-fold for digoxin , but were reduced by 0.694- and 0.429-fold for fexofenadine, respectively.”
Altered oral bioavailability and pharmacokinetics of P-glycoprotein substrates by coadministration of biochanin A.
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback