supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
drug:
Digitoxin
supplement:
Progesterone
Research Papers that Mention the Interaction
“DG and digitoxin (DT), but not ouabain, inhibit the progesterone , pregnenolone, and corticosterone secretion by rat granulosa cells, luteal cells, and zona fasciculata‐reticularis (ZFR) cells, respectively.”
Mechanisms of digoxin and digitoxin on the production of corticosterone in zona fasciculata‐reticularis cells of ovariectomized rats“Digoxin or digitoxin , but not ouabain, decreased the basal and human chorionic gonadotropin (hCG)‐stimulated progesterone secretion as well as the activity of cytochrome P450 side chain cleavage enzyme (P450scc) in luteal cells.”
“These new findings indicated that (1) digoxin or digitoxin inhibited pregnenolone production by decreasing the activity of P450scc enzyme, but not Na+–…, resulting in a decrease on progesterone secretion in rat luteal cells, and (2) the inhibitory effect on pregnenolone production by digoxin or digitoxin was reversed … by progesterone.”
“Digoxin (10−7 – 10−5 M) or digitoxin (10−7 – 10−5 M) decreased the basal and human chorionic gonadotropin (hCG)‐stimulated release of progesterone from rat granulosa cells.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback