“From these investigations it could be concluded that Q and V had a clinically significant effect on pharmacokinetics and pharmacodynamics of DGT but to a lesser extent and, at least in part, by different mechanism than shown for digoxin.”
“While the antagonistic effects of Q and V on QT-duration and myocardial performance with increasing DGT plasma levels nearly disappeared, the synergistic effects of DGT and Q or V were continuously intensified.”