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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
drug:
Diflunisal
supplement:
Serum Albumin, Human
Research Papers that Mention the Interaction
“… diflunisal exhibits high … I of HSA and the three uraemic toxins bind primarily to site II, strong interaction was observed between the drug and the three toxins, which … the binding of diflunisal on its primary class of binding sites on both BSA and HSA molecules and on human plasma.”
In‐vitro study on the competitive binding of diflunisal and uraemic toxins to serum albumin and human plasma using a potentiometric ion‐probe technique“Under conditions where Tyr411 is not acylated, the molar fraction of diazepam, diflunisal , ibuprofen, and 3-indoxyl-sulfate bound to HSA is higher than 0.9 whereas the molar fraction of propofol bound to HSA is ca.”
“The data suggest that covalent binding of DF to HSA via DAG and iso-DAG occurs by different mechanisms (presumably transacylation and glycation, respectively) at different sites (benzodiazepine and warfarin, respectively) whereas reversible binding occurs primarily at the same site (benzodiazepine).”
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