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Last Updated: 5 days ago

Possible Interaction: Diflunisal and Oleic Acid

supplement:

Oleic Acid

Research Papers that Mention the Interaction

At the relevant total and free drug concentrations, the inhibitory effect of oleic acid on drug binding and its influence on drug-induced displacement of T4 were concordant in the order: meclofenamic acid greater than aspirin greater than mefenamic acid greater than diflunisal greater than furosemide greater than fenclofenac.
Increments in added oleic acid (0.5-2.0 mmol/L) progressively increased the mean unbound fractions of [14C]aspirin, [14C] diflunisal , and [14C]furosemide, but did not displace [14C]fenclofenac.
Oleic acid (1 mmol/L) alone did not inhibit serum protein binding of T4, but this concentration augmented the inhibitory effects on T4 binding of diflunisal , mefenamic acid, meclofenamic acid, and aspirin.
The Journal of clinical endocrinology and metabolism  •  1991  |  View Paper
In vitro displacement studies showed that oleic acid is a competitive inhibitor for the binding of diflunisal to human serum albumin.
Clinical pharmacology and therapeutics  •  1980  |  View Paper