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Discover Supplement-Drug Interactions

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Possible Interaction: Diflunisal and Oleic Acid


Oleic Acid

Research Papers that Mention the Interaction

At the relevant total and free drug concentrations, the inhibitory effect of oleic acid on drug binding and its influence on drug-induced displacement of T4 were concordant in the order: meclofenamic acid greater than aspirin greater than mefenamic acid greater than diflunisal greater than furosemide greater than fenclofenac.
Increments in added oleic acid (0.5-2.0 mmol/L) progressively increased the mean unbound fractions of [14C]aspirin, [14C] diflunisal , and [14C]furosemide, but did not displace [14C]fenclofenac.
Oleic acid (1 mmol/L) alone did not inhibit serum protein binding of T4, but this concentration augmented the inhibitory effects on T4 binding of diflunisal , mefenamic acid, meclofenamic acid, and aspirin.
The Journal of clinical endocrinology and metabolism  •  1991  |  View Paper
In vitro displacement studies showed that oleic acid is a competitive inhibitor for the binding of diflunisal to human serum albumin.
Clinical pharmacology and therapeutics  •  1980  |  View Paper