Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Diethylstilbestrol and Vitamin C

Research Papers that Mention the Interaction

17beta-estradiol, synthetic estrogen diethylstilbestrol , and partial agonist tamoxifen were found to inhibit ascorbic acid accumulation in a dose-dependent fashion.
European journal of pharmacology  •  1998  |  View Paper
Moreover, vitamin C lowers the concentration of diethylstilbestrol-4',4"-quinone , the genotoxic metabolite of diethylstilbestrol, in vitro and in Syrian hamsters treated with stilbene.
Vitamin C also decreases the levels in hamsters of diethylstilbestrol-DNA adducts formed by the quinone metabolite.
The American journal of clinical nutrition  •  1991  |  View Paper
Concomitant administration of vitamin C and diethylstilbestrol (DES) decreased concentrations of the major DES-DNA adduct by 70-90% in liver, kidney and testis than those receiving DES only.
Dietary supplementation of vitamin C to diethylstilbestrol (DES)- or estradiol-treated male Syrian hamsters is known to inhibit renal carcinogenesis by approximately 50%.
Carcinogenesis  •  1989  |  View Paper
DES Q concentrations were also examined after injection of DES into hamsters pretreated with vitamin C or alpha-naphthoflavone, substances known to inhibit DES-induced renal carcinogenesis.
Carcinogenesis  •  1989  |  View Paper
Using adrenal ascorbic acid alterations as evidence for ACTH-release (Sayers, 1950), it has been found that following a single injection of stilbestrol there is a marked decrease of vitamin C in the female hamster but only a moderate decrease in the male (Wexler, 1951).
Endocrinology  •  1952  |  View Paper