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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Diethylstilbestrol
supplement:
Tyrosine
Research Papers that Mention the Interaction
“Although DES did not affect sperm viability, motility, penetration into viscous media, tyrosine phosphorylation or the acrosome reaction, it suppressed progesterone-stimulated Ca2+ signaling and tyrosine phosphorylation.”
“WIDER IMPLICATIONS OF THE FINDINGS The present study revealed that DES interfered with progesterone-stimulated Ca2+ signaling and tyrosine phosphorylation, ultimately inhibited progesterone-induced human sperm functions and, thereby, might impair sperm fertility.”
Diethylstilbestrol activates CatSper and disturbs progesterone actions in human spermatozoa“Moreover, DES exposure resulted in the enhanced tyrosine phosphorylation of p53 to a tune of 3.6 fold.”
“The results of this study suggest that p53 protein is phosphorylated at tyrosine residues and enhanced tyrosine phosphorylation of p53 by DES exposure may play a role in the proliferation of hamster renal tubular epithelial cells.”
Stilbene estrogen-mediated enhanced tyrosine phosphorylation of the nuclear protein p53 by nuclear matrix associated tyrosine kinase(s).
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