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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Diethylstilbestrol and Kaempferol

Research Papers that Mention the Interaction

Diethylstilbestrol (DES)-induced cell proliferation was inhibited in a dose-dependent manner by cotreatment with luteolin.
International journal of oncology  •  1996  |  View Paper
An increase in both labeling index and growth fractions by DES exposure was also significantly reversed by co-treatment with luteolin.
Cotreatment with luteolin plus DES led to a 64% decrease in the cells in G1 phase (p<0.05), whereas cells in S phase were reduced by 55% (p<0.05) as compared with DES alone.
The co-treatment with luteolin significantly reversed the effect of DES on the proliferative activity in all structures of mammary gland.
luteolin co-treatment protected … (T-pot) by DES by increasing the potential doubling time from 22-24 h to 33-38 h. Also, co-treatment with luteolin plus DES … conversion of a small percentage of the gland to Lob 2 and Lob 3 compared to DES treated female rats.
International journal of oncology  •  1995  |  View Paper