Possible Interaction: Diethylstilbestrol and Glucose

“The results suggest that cortisol, corticosterone and DES may possibly stimulate the co-transport of glucose and excitation of membrane potential while progesterone and testosterone inhibit them in the brain of O. mossambicus by regulating the activity of Na(+)-K+ ATPase.”

“3,3′‐diallyldiethylstilbestrol DADES ), a blocker of the facilitated diffusion of glucose , was found to interfere markedly with the hydrosmotic response to antidiuretic hormone and its related agonists.”

“The results showed that 50 microM diethylstilbestrol inhibited histamine release from rat peritoneal mast cells in the presence and absence of glucose , but did not affect 45Ca uptake stimulated by concanavalin A. Diethylstilbestrol also inhibited histamine release induced by compound 48/80, exogenous ATP, or ionophore A23187.”

“Addition of DES with glucose caused a large decrease in rate inS. cerevisiae but had much less effect on the other species.”

“The changes in intracellular pH on the addition of glucose correlated well with glucose-induced changes in external pH. Preincubation of cells in the presence of the plasma membrane H(+)-ATPase inhibitor diethylstilbestrol reduced extracellular acidification and intracellular alkalinisation on the addition of glucose.”

“Progesterone, desoxycorticosterone (DOC), diethylstilbestrol , and 5 β-H steroids such as etiocholanolone, considerably accelerated the leakage of anions, glucose , and glycine into the surrounding medium, as did Triton and streptolysin.”

“Also, stilbestrol inhibited both respiration and fermentation when glucose was present.”

“With glucose present, stilbestrol inhibited both respiration and fermentation of yeast, the inhibitory action becoming more marked with increasing reagent concentrations.”