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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
drug:
Diethylstilbestrol
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“In depolarized rat detrusor muscle stimulated with different concentrations of calcium ions , the contractile responses were significantly reduced by the addition of diethylstilboestrol.”
The direct effects of diethylstilboestrol and nifedipine on the contractile responses of isolated human and rat detrusor muscles“ Abstract Diethyl stilbestrol (DES), in very low concentrations (2.4 μg/ml incubation medium), inhibited the uptake of Ca by mitochondria but had little effect on microsomal Ca-uptake.”
“Compounds bearing ethyl substituents DES and THC derivatives) inhibited thrombin-induced release of calcium from the endoplasmic reticulum.”
“Treatment with DDT, MTC, DES , or E2 increased cellular Ca uptake, and the expression of trophoblast‐specific human Ca binding protein (HCaBP) was down‐regulated by both MTC and DDT.”
“Fig. 1 illustrates Albright’s original study, in which he showed that 1 mg of stilboestrol reversed the negative calcium and phosphate balance of an osteoporotic woman and that 15 mg put her into positive balance.”
“ Diethyl-stilboestrol (25 microM), which also inhibits Ca influx in smooth muscle, had a stronger inhibitory effect than felodipine on [3H]NA release induced by high K and addition of Ca.”
The influence of felodipine and diethyl-stilboestrol on [3H]noradrenaline release in the rat trachea.“It is concluded that DES potentiates the twitch response and prolongs the relaxation time by inhibition of the calcium re-uptake by the sarcoplasmic reticulum.”
“The diethylstilbestrol caused a big reduction of the C.N.U. in the female, but not in the male, parallel to an inhibition of laying, and an increase of corporal retention of used calcium.”
“Furthermore, DES inhibits the decay of the ionomycin-induced calcium signal , suggesting an interference of DES with the extrusion of calcium from the cell.”
Role of extracellular calcium and calcium stores in the intracellular calcium rise induced by diethylstilboestrol in C6 rat glioma cells.
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