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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Diethylstilbestrol
supplement:
Allyl Sulfide
Research Papers that Mention the Interaction
“Additionally, 1μM DAS was effective in significantly reducing DES (100μM)-induced lipid peroxidation after 3h.”
“At the same time point, 1, 10, and 100μM DAS were all effective in significantly reducing DES (100μM)-induced strand breaks to near that of the vehicle control.”
“ DES (10μM) in combination with 1, 10, or 100μM DAS resulted in a 31%, 34%, or 36% respective increase in cell viability compared to the DES treatment alone, after 24h.”
Diallyl sulfide inhibits diethylstilbestrol induced DNA damage in human breast epithelial cells (MCF-10A)“Previously, we have shown that DAS inhibits the production of DES induced DNA adducts when given prior to DES.”
“These results suggests that DAS may prevent the formation of DES induced DNA damage by altering the expression of DES metabolizing genes.”
“We hypothesize that DAS alters the expression of genes responsible for DES metabolism.”
Diallyl sulfide induces the expression of estrogen metabolizing genes in the presence and/or absence of diethylstilbestrol in the breast of female ACI rats.“In the present study we have shown that diallyl sulfide (DAS) inhibits the oxidation of DES to DES quinone in all three subcellular fractions (microsomes, mitochondria and nuclei) isolated from breast tissue of female ACI rats.”
“Lineweaver-Burk plots of the rate of DES quinone formation at various DES and DAS concentrations demonstrated that DAS inhibited the oxidation of DES and the reduction of DES quinone in a non-competitive fashion.”
“UV analysis of mitochondrial and microsomal fractions revealed that DAS decreased the rate of DES oxidation to DES quinone and DAS also decreased the rate in which DES quinone was reduced to DES.”
“These results demonstrate that DAS inhibits the production of ROS which suggests that DAS effectively inhibits DES bioactivation in female ACI rats which may have implications for chemopreventive intervention strategies.”
“In addition to directly inhibiting the metabolism of DES, DAS appears to alter the expression of the metabolic machinery such that DES-induced adducts are inhibited.”
“Previously, we have demonstrated that DAS prevents the oxidation and reduction of DES in vitro.”
“These results suggest that DAS directly inhibits the metabolism of DES thus preventing the formation of DNA adducts.”
“We have shown that DES-induced DNA adducts were inhibited in rats that received DAS pre-treatment and co-treatment with DES.”
“We hypothesize that DAS will inhibit the metabolism of DES in vivo thus preventing the formation of DES-induced DNA adducts.”
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