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Discover Supplement-Drug Interactions

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Last Updated: 4 months ago

Possible Interaction: Dietary Fiber and Gemfibrozil

supplement:

Dietary Fiber

Research Papers that Mention the Interaction

The evidence for clinical benefit in outcomes with the use of fibrates is heavily weighted on the use of the older fibrates such as gemfibrozil and clofibrate.
JAMA  •  2011  |  View Paper
In conclusion, the safety profiles of fibrates differ, with a higher rate of liver-related AERs associated with fenofibrate and a higher rate of muscle-related AERs associated with gemfibrozil.
The American journal of cardiology  •  2008  |  View Paper
The three fibrates inhibited CYP2C8 (Ki: bezafibrate 9.7 microM, gemfibrozil 30.4 microM and fenofibrate 92.6 microM) and repaglinide metabolism (IC50: bezafibrate 37.7 microM, gemfibrozil 111 microM and fenofibrate 164 microM), but had no effect on CYP3A4.
Basic & clinical pharmacology & toxicology  •  2005  |  View Paper
Safety concerns about some fibrates such as gemfibrozil may lead to exaggerate precautions regarding fibrate administration and therefore diminish the use of the seagents.
Cardiovascular diabetology  •  2004  |  View Paper