Possible Interaction: Dietary Fiber and Gamma-Aminobutyric Acid

“Afferent fibre excitability is lowered by γ-amino-n-butyric acid and increased by DL-homocysteic acid and L-glutamic acids, actions which are consistent with the effects of these amino acids on nerve cells.”

“In the sensory nodose ganglion of the vagus nerve, many neuronal cell bodies and some fibres were immunoreactive for GABA.”

“Cells of small diametre (less than 30 micrometers) responding to stimulation …) unmyelinated C fibres were studied for 2 reasons: 1) GABA … C fibres but conductance changes have not been determined, 2) the inference that, unlike group … response to GABA by reducing the net influx of Ca++ during action potentials.”

“In S fibres , addition of GABA reduces input membrane resistance (Rm) and e.p.s.p.”

“Membrane conductance in these fibres was markedly increased by γ-aminobutyric acid.”

“ GABA depolarized sural nerve axons and increased the electrical excitability of C‐fibres via GABAA receptor.”