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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Didanosine
supplement:
Resveratrol
Research Papers that Mention the Interaction
“Whereas resveratrol was … microM. However, resveratrol … didanosine at 10 microM, but no synergistic effects were observed for either of the metabolites at up to 300 microM. Nevertheless, the … the fact that the ubiquitously existing human beta-glucuronidase could convert the metabolites back to resveratrol locally or systematically in vivo.”
Resveratrol glucuronides as the metabolites of resveratrol in humans: characterization, synthesis, and anti-HIV activity.“In a resting cell model of T lymphocytes which were infected with HTLV‐IIIB, RV plus ddI in combination, but not individually, suppressed establishment of a productive viral infection.”
“In addition, RV plus ddI markedly inhibited the replication of four ddI‐resistant viral isolates, three of which presented mutations in the RT gene conferring RT‐multidrug resistance.”
“In phytohemagglutinin (PHA)‐activated peripheral blood mononuclear cells (PBMCs) infected with HTLV‐IIIB, 10 &mgr;M RV reduced the 90 % inhibitory concentration (IC90) of AZT, ddC, and ddI by 3.5‐, 5.5‐, and 17.8‐fold, respectively.”
“We now report that resveratrol (RV) synergistically enhances the anti‐HIV‐1 activity of the nucleoside analogues zidovudine (AZT), zalcitabine (ddC), and didanosine (ddl).”
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