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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Didanosine
supplement:
Levocarnitine
Research Papers that Mention the Interaction
“Apoptotic CD4 and CD8 cells, lymphocytes with disrupted mitochondrial membrane potential, and lymphocytes undergoing oxidant stress were greatly reduced in subjects treated with AZT and DDI plus L-carnitine compared with those who did not receive L-carnitine.”
L-carnitine reduces lymphocyte apoptosis and oxidant stress in HIV-1-infected subjects treated with zidovudine and didanosine.“On … hand l-carnitine , in association with the mitochondrial cardiolipins, inhibits myopathy … continued prescription of drugs [AZT (zidovudine), ddl ( didanoside ), or ddC (zalcitabine)], and the redox couple of α-lipoic-dihydrolipoic acid prevents production of … reactive oxygen species that trigger apoptosis of infected cells, with sphingomyelin breakdown to ceramides.”
“Studies show that d4T and ddI may cause neuropathy by lowering L-acetyl-carnitine levels; however, there have been no controlled studies showing that L-acetyl-carnitine therapy is effective.”
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