Possible Interaction: Dicumarol and Vitamin K

“ Dicumarol also induced oxidative stress as evidenced by increased total glutathione and oxidized glutathione, as well as sensitizing to cell killing mediated by menadione.”

“When pretreated with the DT diaphorase inhibitor, dicoumarol , HepG2 cells exhibited a marked exacerbation of genotoxicity in the presence of either MND or PQ, indicating protective influence of the enzyme.”

“Moreover, we have found that the cytotoxic effects of DBNQ on human tumor and murine bone marrow stem cells can be prevented or lessened by pretreatment of the cells with dicoumarol , a potent inhibitor of DT-diaphorase.”

“It utilized a wide range of electron acceptors including dichlorophenolindophenol (DCPIP), nitroblue tetrazolium (NBT), ferricyanide, and quinones menadione , benzoquinone), but not pyridinium cations (paraquat and N-methyl-beta-carbolines), and it was inhibited by dicoumarol and diphenyliodonium.”

“ Dicoumarol , a bacterial antagonist of vitamin K in spoiled sweet clover, was recognized as the agent responsible for a fatal hemorrhagic disease in livestock by Karl Link and Wilhelm Schoeffel of the University of Wisconsin.”

“ MEN depleted glutathione to a small extent in the HT-29 cell line, but a rapid depletion similar to Caco-2 cells was achieved when dicoumarol was added.”

“ Dicumarol (an inhibitor of DT diaphorase) enhanced the capacity of menadione to induce Hep 3B cell degeneration from 71.3% to 86.2% after 120 min of menadione treatment at 37 degrees C, but did not have this effect in Hep G2, CCRF-CEM or MOLT-3 cells.”

“During the stage of recovery from bishydroxycoumarin administration under the influence of the administration of vitamin K1 ; further dissociation may be observed in the behavior of the clotting agents affected by the anticoagulant.”

“Their studies show that in certain species ascorbic acid, like vitamin K , can antagonize the action of Dicumarol and that in scurvy the hypoprothrombinemic effect of Dicumarol is enhanced.”

“SummaryThe anticoagulant, dicumarol , inhibits the vitamin K cycle by blocking the conversion of the vitamin K epoxide.”