Possible Interaction: Dicumarol and NADH

“Extensive metabolism (greater than 90%) of AZQ (100 microM) in HT-29 cytosol occurred, which was either NADH or NADPH dependent and could be inhibited by dicumarol.”

“β-lap treatment generated reactive oxygen species (ROS), which were efficiently blocked by dicoumarol , an inhibitor of NADH dehydrogenases.”

“The rate of formation of the CoQ1 sulfate conjugate was markedly increased by the addition of NADH and was prevented by dicumarol , a DT‐diaphorase (NQO1) inhibitor.”

“It uses NADH or NADPH as reductants with equal facility and is potently inhibited by dicoumarol and similar anticoagulants.”

“ Dicoumarol , an inhibitor of NAD(P)H-quinone oxidoreductase (NQO), dose dependently suppressed the NADH oxidation in the outer membrane via PQ as well as menadione, with I50 values of 190 (for menadione) and 150 microM (for PQ).”

“ Dicumarol at 100 microM inhibited the NADH :cytochrome b5 reductase-catalyzed reduction of mitomycin C by 24% and by 57% at 300 microM. The degree of inhibition of the enzyme by dicumarol was the same at both pH 6.6 and 7.6.”

“While these fenomena seem directly related to the inhibitory action of dicoumarol on the overall p -nitroanisole demethylase reaction, an inhibitory effect of dicoumarol on NADH : ferricyanide reductase, on the contrary, was shown not to be related to the inhibition of the demethylation process.”

“ NADH respiration in isolated membrane particles were partially inhibited by rotenone, dicoumarol , quinacrine, flavone, and capsaicin.”

“ Dicoumarol and Cibacron Blue 3GA are competitive inhibitors of NADH oxidation.”

“ Dicoumarol is a potent inhibitor competitive vs. NADH with a Ki of 62 nM. Several compounds containing a carboxyl group are also competitive inhibitors vs. NADH.”