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Possible Interaction: Dicumarol and NADH



Research Papers that Mention the Interaction

Extensive metabolism (greater than 90%) of AZQ (100 microM) in HT-29 cytosol occurred, which was either NADH or NADPH dependent and could be inhibited by dicumarol.
Cancer research  •  1990  |  View Paper
β-lap treatment generated reactive oxygen species (ROS), which were efficiently blocked by dicoumarol , an inhibitor of NADH dehydrogenases.
Cell cycle  •  2015  |  View Paper
The rate of formation of the CoQ1 sulfate conjugate was markedly increased by the addition of NADH and was prevented by dicumarol , a DT‐diaphorase (NQO1) inhibitor.
BioFactors  •  2003  |  View Paper
It uses NADH or NADPH as reductants with equal facility and is potently inhibited by dicoumarol and similar anticoagulants.
Biochemical Society transactions  •  1999  |  View Paper
Dicoumarol , an inhibitor of NAD(P)H-quinone oxidoreductase (NQO), dose dependently suppressed the NADH oxidation in the outer membrane via PQ as well as menadione, with I50 values of 190 (for menadione) and 150 microM (for PQ).
Archives of biochemistry and biophysics  •  1998  |  View Paper
Dicumarol at 100 microM inhibited the NADH :cytochrome b5 reductase-catalyzed reduction of mitomycin C by 24% and by 57% at 300 microM. The degree of inhibition of the enzyme by dicumarol was the same at both pH 6.6 and 7.6.
Cancer research  •  1993  |  View Paper
While these fenomena seem directly related to the inhibitory action of dicoumarol on the overall p -nitroanisole demethylase reaction, an inhibitory effect of dicoumarol on NADH : ferricyanide reductase, on the contrary, was shown not to be related to the inhibition of the demethylation process.
Biochemical pharmacology  •  1973  |  View Paper
NADH respiration in isolated membrane particles were partially inhibited by rotenone, dicoumarol , quinacrine, flavone, and capsaicin.
Scientific reports  •  2021  |  View Paper
Dicoumarol and Cibacron Blue 3GA are competitive inhibitors of NADH oxidation.
Archives of biochemistry and biophysics  •  2009  |  View Paper
Dicoumarol is a potent inhibitor competitive vs. NADH with a Ki of 62 nM. Several compounds containing a carboxyl group are also competitive inhibitors vs. NADH.
Biochimica et biophysica acta  •  1998  |  View Paper
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