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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Diclofenac
supplement:
Vitamin B 12
Research Papers that Mention the Interaction
“Documented effects were observed when 0.1 mg/kg of vitamin B12 was concurrently used with 1 mg/kg of diclofenac and or 0.2 mg/kg of celecoxib.”
Effect of vitamin B12 on functional recovery and histopathologic changes of tibial nerve-crushed rats.“Co-treatments with vitamin B12 and diclofenac produced more antinociceptive effects.”
“Systemic co-administrations of vitamin B12 and diclofenac increased vitamin B12-induced antinociception.”
“Oral administration of a vitamin B complex preparation containing thiamine (vitamin B(1)), pyridoxine (vitamin B(6)), and cyanocobalamin (vitamin B(12)) in a 1:1:0.01 proportion did not produce any antinociception by itself, but it significantly potentiated the effect of diclofenac.”
“Significant antinociceptive effects were observed after combined treatments of diclofenac (6.25 and 12.50 µg per rat) with vitamin B12 (0.63 and 2.50 µg per rat), respectively.”
Effects of intracerebroventricular injection of vitamin B12 on formalin-induced muscle pain in rats: Role of cyclooxygenase pathway and opioid receptors“Moreover, a potentiation effect was observed between vitamin B12 and diclofenac.”
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