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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Diclofenac
supplement:
Vadimezan
Research Papers that Mention the Interaction
“Based on our in vitro inhibition studies, we predicted a 20% increase in DMXAA AUC in mice with concomitant diclofenac , but little or no effect (<5%) with L-thalidomide.”
“Results: Diclofenac at 100 µM caused significant inhibition of glucuronidation (>70%) and 6-methylhydroxylation (>54%) of DMXAA in mouse and human liver microsomes.”
In vitro and in vivo kinetic interactions of the antitumour agent 5,6-dimethylxanthenone-4-acetic acid with thalidomide and diclofenac“In contrast, when combined with diclofenac or cyproheptadine, the plasma AUC of DMXAA was significantly (P<0.05) increased by 48% and 88% and the T1/2 by 36% and 107%, respectively, compared to controls.”
“Purpose: Coadministration of thalidomide, cyproheptadine or diclofenac has been shown to increase the area under the plasma concentration-time curve (AUC) of the novel antitumour agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in mice.”
A difference between the rat and mouse in the pharmacokinetic interaction of 5,6-dimethylxanthenone-4-acetic acid with thalidomide
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