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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Diclofenac and Vadimezan

supplement:

Vadimezan

Research Papers that Mention the Interaction

Based on our in vitro inhibition studies, we predicted a 20% increase in DMXAA AUC in mice with concomitant diclofenac , but little or no effect (<5%) with L-thalidomide.
Results: Diclofenac at 100 µM caused significant inhibition of glucuronidation (>70%) and 6-methylhydroxylation (>54%) of DMXAA in mouse and human liver microsomes.
Cancer Chemotherapy and Pharmacology  •  2014  |  View Paper
In contrast, when combined with diclofenac or cyproheptadine, the plasma AUC of DMXAA was significantly (P<0.05) increased by 48% and 88% and the T1/2 by 36% and 107%, respectively, compared to controls.
Purpose: Coadministration of thalidomide, cyproheptadine or diclofenac has been shown to increase the area under the plasma concentration-time curve (AUC) of the novel antitumour agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in mice.
Cancer Chemotherapy and Pharmacology  •  2001  |  View Paper