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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Diclofenac and Serum Albumin, Human

Research Papers that Mention the Interaction

Three-dimensional fluorescence spectroscopy clearly demonstrated the occurrence of conformational changes of HSA with addition of DF-Na.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy  •  2013  |  View Paper
We present evidence that HSA modifications by diclofenac in vivo are complicated and variable, that at least a fraction of these modifications are derived from the drug’s AG metabolite, and that albumin adduction is not inevitably a causation of hypersensitivity to carboxylate drugs or a coincidental association.
The Journal of Pharmacology and Experimental Therapeutics  •  2014  |  View Paper
Addition of HSA resulted in smaller Km,u values for diclofenac and terfenadine metabolism by CYP2C9 and CYP3A4, respectively, and the Ki,u value for ketoconazole inhibition of CYP3A4 was also reduced.
Drug metabolism and pharmacokinetics  •  2002  |  View Paper