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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Diclofenac
supplement:
Quercetin
Research Papers that Mention the Interaction
“Furthermore, quercetin treatment significantly decreased metabolic ratios of Cmax and AUC0‐∞ suggesting that reduced formation of DIC to 4‐OHDIC.”
“In addition, geometric mean ratios and 90% confidence intervals for Cmax and AUC0‐∞ of DIC and 4‐OHDIC were both out of the no‐effect limits of 0.80–1.25, which indicates a significant pharmacokinetic interaction between quercetin and DIC.”
“The results suggest that quercetin might have inhibited CYP2C9‐mediated metabolism of DIC.”
“Treatment with quercetin significantly enhanced maximum plasma concentration (Cmax), area under the curve (AUC0‐∞), and half life, while significantly decreased elimination rate constant (kel) and apparent oral clearance (CL/F) of DIC compared with control.”
Evaluation of the effect of quercetin treatment on CYP2C9 enzyme activity of diclofenac in healthy human volunteers“Hence, it can be concluded that metabolism of diclofenac and chlorzoxazone was substantially reduced upon quercetin treatment.”
“In this study, quercetin treatment significantly enhanced the exposure of diclofenac , a CYP2C9 substrate, in heathy volunteers.”
“Steroid hormones (17beta-estradiol, progesterone and cortisol), flavonoids (genistein and quercetin ) and non-steroidal anti-inflammatory drugs (NSAIDs) (indomethacin and diclofenac ) inhibit [(14)C]AA uptake in a dose-dependent and non-competitive manner.”
“The peoral use of quercetin before and after administration of diclofenac sodium has been shown to be associated with fewer ulcers in test animals, which fact suggests to us a protective effect of quercetin on their gastric mucosa.”
[Effect of quercetin on sodium diclofenac-induced ulceration].“Nevertheless, only the COX-2 activity induced by DIC was prevented in the presence of QUER (63.2 ± 3.0 versus 60.1 ± 1.0 and 56.6 ± 1.3 versus 58.1 ± 2.4 at 1 and 3 h, respectively).”
Quercetin decreases the antinociceptive effect of diclofenac in an arthritic gout-pain model in rats.“For instance, the production of polyphenols (such as quercetin ) in the plant increased after diclofenac incubation.”
“It was established in the previous studies that quercetin prevented the development and caused faster regression of ulcers, petechia and anabroses in rats, which were induced by diclofenac taking.”
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