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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Diclofenac
supplement:
Melatonin
Research Papers that Mention the Interaction
“In vivo experiments showed that SD altered the mice stomach mucosa and induced tissue damage that was prevented by MLT.”
“The histological evaluation of pig intestine samples showed that SD induced the villi alteration, which was prevented by MLT.”
Study of Melatonin as Preventive Agent of Gastrointestinal Damage Induced by Sodium Diclofenac“The main aim of this … show whether the effects of Mel can prevent … effects of diclofenac sodium (DS), used as a non-steroidal anti-inflammatory drug (NSAID) during the prenatal period, on the … brain tissues using stereological methods Twenty-four male 12-week old Wistar albino rats were used.”
“However, usage of the MEL with the DS caused preventing of these pathological alterations in the kidney.”
“In addition, we determined that usage of the MEL with the DS caused increases in the mean volume, numerical density, and total number of the glomeruli (p < 0.05).”
“The current study indicates that prenatal exposure to DS decreases the number and the diameter of sciatic nerve axons and that melatonin prophylaxis can prevent these effects.”
“Highlights • The toxic effects of diclofenac (DF) seemed to be sustained after withdrawal.• DF appeared to be more toxic post-administration.• Melatonin could attenuate the toxic effects of DF.”
Elevated reproductive toxicity effects of diclofenac after withdrawal: Investigation of the therapeutic role of melatonin
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