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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Diclofenac
supplement:
Hesperetin
Research Papers that Mention the Interaction
“The demonstration that diosmetin and hesperetin inhibit CYP2C9-mediated diclofenac metabolism at low micromolar concentrations is of potential clinical relevance because CYP2C9 is responsible for the biotransformation of various therapeutically important drugs that have narrow therapeutic indexes.”
Flavonoids diosmetin and hesperetin are potent inhibitors of cytochrome P450 2C9-mediated drug metabolism in vitro.
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